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white powder consisting of submicroscopic spherical particles of rather uniform size (i., narrowparticle size distribution). micro-scopic examination or an x-ray diffraction measurement maybe used to monitor these parameters.in some instances it is necessary to use an ointment base thatis less than ideal, to achieve the required stability. pyloriinfection and duodenal ulcer disease (active or 1-year history of a duodenal ulcer)whoare either allergic or intolerant to clarithromycin or in whom fertility drugs for sale clomid resistance to clarithromycin isknown or suspected. although it is somewhatdifficult to categorize such major changes, this issue has beendescribed in a series of fda guidance documents related toscale-up and post-approval changes (supac).drug characteristics related to solubility and permeabilitymay allow a reasonable expectation that the drug is unlikelyto be subject to significant bioavailability problems. although ed (impotence) can afflict anyone from 13 to 90 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